Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

DNA repair ensures genomic stability to achieve healthy ageing, including cognitive
maintenance. Mutations on genes encoding key DNA repair proteins can lead to diseases …

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature
aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase …

Aging is the primary driver of various diseases, including common neurodegenerative
diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Currently there is …

Werner Syndrome (WS) is an autosomal recessive disorder characterized by premature
aging due to mutations of the WRN gene. A classical sign in WS patients is short stature, but …

Nicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health
through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the …

Mitochondria are the primary cellular energy generators, supplying the majority of
adenosine triphosphate through oxidative phosphorylation, which is necessary for neuron …

Nicotinamide adenine dinucleotide (NAD+) is an important natural molecule involved in
fundamental biological processes, including the TCA cycle, OXPHOS, β-oxidation, and is a …

The evolution of the circulatory system from invertebrates to mammals has involved the
passage from an open system to a closed in-parallel system via a closed in-series system …

Aging is a complex process that affects multiple organs, and the discovery of a
pharmacological approach to ameliorate aging is considered the Holy Grail of medicine …