Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

Aryl amines are one of the most common moieties in biologically active molecules, and
approximately 37% of drug candidates contain aromatic amines. Recent advancements in …

Alkylamine structures represent one of the most functional and widely used in organic
synthesis and drug design. However, the general methods for the functionalization of the …

Abstract Although 2‐furyl‐carbenes (furfurylidenes) are prone to instantaneous electrocyclic
ring opening, chiral [BiRh]‐paddlewheel complexes empowered by London dispersion …

Despite the importance of heteroatom‐substituted cyclopropane derivatives in drug design
and organic synthesis, cyclopropanethiols remain critically underexplored. Inspired by the …

Isosteric replacement of functional groups is an emerging strategy for optimizing bioactive
molecules in drug discovery. tert-Butyl group is a particularly important moiety, yet its …

Lipid nanoparticles (LNPs) are an essential component of messenger RNA (mRNA)
vaccines and genome editing therapeutics. Ionizable amino lipids, which play the most …

1, 4-Disubstituted cubyl aryl thioethers were generated from the corresponding iodocubanes
and aryl thiolates upon UV irradiation in dimethyl sulfoxide at room temperature. This simple …

We are reporting the preparation and use in cross‐coupling reactions of a newly developed,
bench‐stable (1‐fluorocyclopropyl) metalloid reagent. The Stille cross‐coupling reaction …

Endocyclic 1-azaallyl anions engage allyl acetates in a palladium-catalyzed allylation
followed by reduction to give unprotected 2-(hetero) aryl-3-allylpiperidines and 2-allyl-3 …