▪ Abstract In addition to CD4, the human immunodeficiency virus (HIV) requires a coreceptor
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …

The human immunodeficiency virus–type 1 (HIV-1) envelope glycoproteins interact with
receptors on the target cell and mediate virus entry by fusing the viral and cell membranes …

How the covalent modification of mRNA ribonucleotides, termed epitranscriptomic
modifications, alters mRNA function remains unclear. One issue has been the difficulty of …

Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are highly related members of
the CC chemokine subfamily. Despite their structural similarities, MIP-1α and MIP-1β show …

ABSTRACT T-20 is a synthetic peptide that potently inhibits replication of human
immunodeficiency virus type 1 by interfering with the transition of the transmembrane …

The entry of primate immunodeficiency viruses into target cells depends on a sequential
interaction of the gp120 envelope glycoprotein with the cellular receptors, CD4 and …

The AIDS pandemic continues to spread unchecked in many parts of the world, with greater
than 34 million individuals currently infected with human immunodeficiency virus (HIV) …

HIV-1 enters its target cells by fusion at the plasma membrane. The primary cellular receptor
for HIV is CD4, but this molecule is insufficient to permit viral fusion. During 1996, the …

In a previous study we showed that budding of HIV-1 particles occurs at highly specialized
membrane microdomains known as lipid rafts. These microdomains are characterized by a …

Background: The gp120 exterior envelope glycoprotein of HIV-1 binds sequentially to CD4
and chemokine receptors on cells to initiate virus entry. During natural infection, gp120 is a …