Review for disease of the year: epidemiology of juvenile idiopathic arthritis and its associated uveitis: the probable risk factors

A Heiligenhaus, C Heinz, C Edelsten… - Ocular Immunology …, 2013 - Taylor & Francis
Juvenile idiopathic arthritis (JIA) is the most common systemic disease associated with
uveitis in childhood. The frequency of JIA-associated uveitis (JIAU) varies geographically …

Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study

PC Haycock, S Burgess, A Nounu, J Zheng… - JAMA …, 2017 - jamanetwork.com
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

The etiology of juvenile idiopathic arthritis

D Rigante, A Bosco, S Esposito - Clinical reviews in allergy & immunology, 2015 - Springer
Over the years, the commonly used term to describe juvenile idiopathic arthritis (JIA) has
changed. By definition, JIA includes all types of arthritis with no apparent cause, lasting more …

Dense genoty** of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

A Hinks, J Cobb, MC Marion, S Prahalad, M Sudman… - Nature …, 2013 - nature.com
We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …

[PDF][PDF] Paediatric rheumatology

RE Petty - Egyptian Pharmaceutical Journal, 2012 - journals.ekb.eg
The last decade has witnessed rapid growth in awareness of the rheumatic diseases of
childhood, an enhanced understanding of many of the unique aspects of their presentation …

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

MJ Ombrello, VL Arthur, EF Remmers… - Annals of the …, 2017 - ard.bmj.com
Objectives Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified
by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA …

Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis

Y Yin, X Yang, S Wu, X Ding, H Zhu, X Long… - Nature …, 2022 - nature.com
Appropriate regulation of B cell differentiation into plasma cells is essential for humoral
immunity while preventing antibody-mediated autoimmunity; however, the underlying …

Identification of four novel loci in asthma in European American and African American populations

B Almoguera, L Vazquez, F Mentch… - American journal of …, 2017 - atsjournals.org
Rationale: Despite significant advances in knowledge of the genetic architecture of asthma,
specific contributors to the variability in the burden between populations remain uncovered …

Genome‐Wide Association Meta‐Analysis reveals novel juvenile idiopathic arthritis susceptibility Loci

LA McIntosh, MC Marion, M Sudman… - Arthritis & …, 2017 - Wiley Online Library
Objective Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease
and has a strong genomic component. To date, JIA genetic association studies have had …

Nutrient sensing, signaling and ageing: the role of IGF-1 and mTOR in ageing and age-related disease

SC Johnson - Biochemistry and Cell Biology of Ageing: Part I …, 2018 - Springer
Nutrient signaling through insulin/IGF-1 was the first pathway demonstrated to regulate
ageing and age-related disease in model organisms. Pharmacological or dietary …