Abstract Purpose of Review The role of wnt signalling in atherogenesis raises the possibility
that the wnt inhibitor, sclerostin, provides a natural defence to this process, and that anti …

Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the
arterial wall. CAD progression involves complex interactions and phenotypic plasticity …

Coronary artery calcification (CAC) is mainly associated with coronary atherosclerosis,
which is an indicator of coronary artery disease (CAD). CAC refers to the accumulation of …

Objective In this study, we aimed to establish the causal effects of lowering sclerostin, target
of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods …

Aims Abdominal aortic aneurysm (AAA) is a common, serious vascular disease with no
effective pharmacological treatment. The nucleoside adenosine plays an important role in …

Trimethylamine N‐oxide (TMAO) is a circulating microbiome‐derived metabolite implicated
in the development of atherosclerosis and cardiovascular disease (CVD). We investigated …

BACKGROUND: Vascular calcification is a detrimental aging pathology markedly
accelerated in patients with chronic kidney disease. PLA (prelamin A) is a biomarker of …

Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary
artery disease (CAD). However, non-European populations are underrepresented in …

Aims Although prior observational studies have suggested that patients with non-alcoholic
fatty liver disease (NAFLD) may have a higher risk of coronary artery calcification (CAC) …

BACKGROUND: Individuals with type 2 diabetes (T2D) have an increased risk of coronary
artery disease (CAD), but questions remain about the underlying pathology. Identifying …