The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important
role in the maintenance of wakefulness, and dysfunction in the histaminergic system has …

The reference tissue model allows for quantification of receptor kinetics without measuring
the arterial input function, thus avoiding arterial cannulation and time-consuming metabolite …

In young, typically develo** children, repetitive behavior similar to that in certain
neuropsychiatric syndromes is common. Whereas this behavior is adaptive in typical …

Tourette's syndrome is a neuropsychiatric syndrome with onset in childhood that is
characterized by chronic multiple tics. The cause of Tourette's syndrome is unknown, but the …

This review aims to relate recent findings describing the role and neural connectivity of the
basal ganglia to the clinical neuropsychiatry of basal ganglia movement disorders and to the …

Background Tics are involuntary, brief, stereotyped motor and vocal behaviors often
associated with irresistible urges. They are a defining symptom of the classic …

Almost since the beginning of research on Tourette syndrome (TS), tics have been linked to
a dysfunction of the dopamine (DA) system. At first, this assumption was mainly based on …

OBJECTIVE: Dopaminergic abnormalities in frontal-subcortical circuits have been
hypothesized as the underlying pathophysiologic mechanism in Tourette's syndrome. The …

A mild and selective photocatalytic C–H 18F-fluorination reaction has been developed that
provides direct access to 18F-fluorinated amino acids. The biodistribution and uptake of …