Unveiling microbial diversity: harnessing long-read sequencing technology

DP Agustinho, Y Fu, VK Menon, GA Metcalf… - Nature …, 2024 - nature.com
Long-read sequencing has recently transformed metagenomics, enhancing strain-level
pathogen characterization, enabling accurate and complete metagenome-assembled …

Unraveling metagenomics through long-read sequencing: a comprehensive review

C Kim, M Pongpanich, T Porntaveetus - Journal of Translational Medicine, 2024 - Springer
The study of microbial communities has undergone significant advancements, starting from
the initial use of 16S rRNA sequencing to the adoption of shotgun metagenomics. However …

SemiBin2: self-supervised contrastive learning leads to better MAGs for short-and long-read sequencing

S Pan, XM Zhao, LP Coelho - Bioinformatics, 2023 - academic.oup.com
Motivation Metagenomic binning methods to reconstruct metagenome-assembled genomes
(MAGs) from environmental samples have been widely used in large-scale metagenomic …

[PDF][PDF] Illuminating the oral microbiome and its host interactions: recent advancements in omics and bioinformatics technologies in the context of oral microbiome …

JL Baker - FEMS Microbiology Reviews, 2023 - academic.oup.com
The oral microbiota has an enormous impact on human health, with oral dysbiosis now
linked to many oral and systemic diseases. Recent advancements in sequencing, mass …

Viruses of sulfur oxidizing phototrophs encode genes for pigment, carbon, and sulfur metabolisms

PJ Hesketh-Best, A Bosco-Santos, SL Garcia… - … Earth & Environment, 2023 - nature.com
Viral infections modulate bacterial metabolism and ecology. Here, we investigated the
hypothesis that viruses influence the ecology of purple and green sulfur bacteria in anoxic …

Accurate binning of metagenomic contigs using composition, coverage, and assembly graphs

V Mallawaarachchi, Y Lin - Journal of Computational Biology, 2022 - liebertpub.com
Metagenomics enables the recovery of various genetic materials from different species, thus
providing valuable insights into microbial communities. Metagenomic binning group …

Bioinformatic tools for NGS-based metagenomics to improve the clinical diagnosis of emerging, re-emerging and new viruses

M Ibañez-Lligoña, S Colomer-Castell… - Viruses, 2023 - mdpi.com
Epidemics and pandemics have occurred since the beginning of time, resulting in millions of
deaths. Many such disease outbreaks are caused by viruses. Some viruses, particularly …

Disentangling cobionts and contamination in long-read genomic data using sequence composition

CC Weber - G3: Genes, Genomes, Genetics, 2024 - academic.oup.com
The recent acceleration in genome sequencing targeting previously unexplored parts of the
tree of life presents computational challenges. Samples collected from the wild often contain …

Improving bacterial metagenomic research through long-read sequencing

N Greenman, SAD Hassouneh, LS Abdelli, C Johnston… - Microorganisms, 2024 - mdpi.com
Metagenomic sequencing analysis is central to investigating microbial communities in
clinical and environmental studies. Short-read sequencing remains the primary approach for …

Solving genomic puzzles: computational methods for metagenomic binning

V Mallawaarachchi, A Wickramarachchi… - Briefings in …, 2024 - academic.oup.com
Metagenomics involves the study of genetic material obtained directly from communities of
microorganisms living in natural environments. The field of metagenomics has provided …