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Matrix metalloproteinases in bone resorption, remodeling, and repair
Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific …
MP Vincenti, CE Brinckerhoff - Arthritis research & therapy, 2002 - Springer
Abstract Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial
collagenases that degrade type II collagen in cartilage; this is a committed step in the …
collagenases that degrade type II collagen in cartilage; this is a committed step in the …
Signaling and transcriptional regulation in osteoblast commitment and differentiation
The major event that triggers osteogenesis is the transition of mesenchymal stem cells into
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
We present an overview of Runx involvement in regulatory mechanisms that are requisite for
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …
Interleukin‐1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c‐Jun N‐terminal kinase, and nuclear factor κB …
Objective To examine the mechanism of interleukin‐1 (IL‐1)–induced collagenase 3 (matrix
metalloproteinase 13 [MMP‐13]) gene expression in cultured chondrocytes for the purpose …
metalloproteinase 13 [MMP‐13]) gene expression in cultured chondrocytes for the purpose …
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
LA Neuhold, L Killar, W Zhao, MLA Sung… - The Journal of clinical …, 2001 - jci.org
It has been suggested that increased collagenase-3 (MMP-13) activity plays a pivotal role in
the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in …
the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in …
Regulation of the osteoblast‐specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways
RT Franceschi, G ** and maturing osteoblasts
Runx2 is essential for osteoblast development and proper bone formation. A member of the
Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate …
Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate …