Atropisomerism is a stereochemical behavior portrayed by three-dimensional molecules that
bear rotationally restricted σ bond. Akin to the well-represented point-chiral molecules …

This tutorial review provides a systematic overview of the available methodologies for the
atroposelective transformation of (heterobiaryl) biaryl precursors toward the synthesis of …

Intellectual curiosity has always been one of the major driving forces leading to new
advances in chemistry. At the onset of the 20th century, the fact that biaryls could be optically …

The biaryl structural motif is a predominant feature in many pharmaceutically relevant and
biologically active compounds. As a result, for over a century1 organic chemists have sought …

A rotationally hindered and thus stereogenic biaryl axis is the structurally and
stereochemically decisive element of a steadily growing number of natural products, chiral …

Eugenol is the major component of clove essential oil and has demonstrated relevant
biological potential with well-known antimicrobial and antioxidant action. Therefore, this …

We herein present a facile and column-free synthetic route toward a structurally unique oxa-
spirocyclic diphenol, termed as O-SPINOL. Features of the synthesis include the …

Reported herein is an enantiodivergent synthesis of chiral biaryls by a chiral phosphoric
acid catalyzed asymmetric transfer hydrogenation reaction. Upon treatment of biaryl lactols …

The first dynamic kinetic asymmetric transformation of racemic biaryl substrates on the basis
of axial-to-central chirality transfer has been realized. Chiral Pd-NHC complexes were found …

Eine rotationsgehinderte und dadurch stereogene Biarylachse ist das strukturell und
stereochemisch entscheidende Element einer ständig wachsenden Zahl von Naturstoffen …