The metabolic syndrome is a multiplex risk factor for atherosclerotic cardiovascular disease
and type 2 diabetes. It is composed of atherogenic dyslipidemia, elevated blood pressure …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Multitargeting compounds comprising activity on more than a single biological target have
gained remarkable relevance in drug discovery owing to the complexity of multifactorial …

The emergence of large-scale genomic, chemical and pharmacological data provides new
opportunities for drug discovery and repositioning. In this work, we develop a computational …

The PPARs are a subfamily of three ligand-inducible transcription factors, which belong to
the superfamily of nuclear hormone receptors. In mammals, the PPAR subfamily consists of …

The development of multitarget-directed ligands (MTDLs) has become a widely focused
research topic, but rational design remains as an enormous challenge. This paper reviews …

Owing to the market competitiveness and urgent societal need, an optimum speed of drug
discovery is an important criterion for successful implementation. Despite the rapid ascent of …

The renin-angiotensin system is a central component of the physiological and pathological
responses of cardiovascular system. Its primary effector hormone, angiotensin II (ANG II), not …

Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis
of natural products. We underscored these achievements in a report published in …

The link between branched-chain amino acids (BCAAs) and obesity has been known for
decades but the functional role of BCAA metabolism in white adipose tissue (WAT) of obese …