An update of the use of thiocarbohydrazides and thiosemicarbazides in the preparation of heterocycles and their biological importance
The inherent reactivity of thiocarbohydrazides and thiosemicarbazides makes them valuable
as building blocks for the synthesis of other heterocyclic motifs. This review article discusses …
as building blocks for the synthesis of other heterocyclic motifs. This review article discusses …
A facile synthesis and anticancer activity of some novel thiazoles carrying 1, 3, 4-thiadiazole moiety
Abstract Background Thiazoles and 1, 3, 4-thiadiazoles have been reported to possess
various pharmacological activities. Results A novel series of thiazoles carrying 1, 3, 4 …
various pharmacological activities. Results A novel series of thiazoles carrying 1, 3, 4 …
A facile access and evaluation of some novel thiazole and 1, 3, 4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents
Background Many heterocyclic compounds containing thiazole or 1, 3, 4-thiadiazole ring in
their skeletons have been reported to possess various pharmacological activities especially …
their skeletons have been reported to possess various pharmacological activities especially …
New hydrazones bearing thiazole scaffold: Synthesis, characterization, antimicrobial, and antioxidant investigation
New series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-(4-
(trifluoromethyl) phenyl) thiazole-5-carbohydrazide with differently substituted …
(trifluoromethyl) phenyl) thiazole-5-carbohydrazide with differently substituted …
[HTML][HTML] Synthesis of 2-phenylamino-thiazole derivatives as antimicrobial agents
A series of 10 new N-phenyl-4-(4-(thiazol-2-yl)-phenyl)-thiazol-2-amine derivatives (3a–j)
and 4 new 5-(2-(phenylamino)-thiazol-4-yl)-benzamide ethers (3′ a–d) were synthesized …
and 4 new 5-(2-(phenylamino)-thiazol-4-yl)-benzamide ethers (3′ a–d) were synthesized …
Novel tryptanthrin hybrids bearing aminothiazoles as potential EGFR inhibitors: Design, synthesis, biological screening, molecular docking studies, and ADME/T …
A variety of novel tryptanthrin aminothiazole analogues 3a‐h and 5a‐h possessing a
biologically active thiazole moiety were synthesized by the reaction of tryptanthrin …
biologically active thiazole moiety were synthesized by the reaction of tryptanthrin …
Study of the Relationships between the Structure, Lipophilicity and Biological Activity of Some Thiazolyl-carbonyl-thiosemicarbazides and Thiazolyl-azoles
Lipophilicity, as one of the most important physicochemical parameters of bioactive
molecules, was investigated for twenty-two thiazolyl-carbonyl-thiosemicarbazides and …
molecules, was investigated for twenty-two thiazolyl-carbonyl-thiosemicarbazides and …
New Thiazolyl-triazole Schiff Bases: Synthesis and Evaluation of the Anti-Candida Potential
In the context of the dangerous phenomenon of fungal resistance to the available therapies,
we present here the chemical synthesis of a new series of thiazolyl-triazole Schiff bases B1 …
we present here the chemical synthesis of a new series of thiazolyl-triazole Schiff bases B1 …
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl) thiazole-5-yl]-4-substituted-3-
substituted benzylthio-4H-1, 2, 4-triazole derivatives were synthesized, and evaluated for …
substituted benzylthio-4H-1, 2, 4-triazole derivatives were synthesized, and evaluated for …
Design, synthesis, biological evaluation, common feature pharmacophore model and molecular dynamics simulation studies of ethyl 4-(phenoxymethyl)-2 …
J Wu, W Li, Z Zheng, X Lu, H Zhang, Y Ma… - Journal of …, 2021 - Taylor & Francis
SHP2 is a non-receptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene
involved in cell death pathway (PD-1/PD-L1) and cell growth and differentiation pathway …
involved in cell death pathway (PD-1/PD-L1) and cell growth and differentiation pathway …