Abstract FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in
many types of cancer. Its highest mutation rate is found in head and neck squamous cell …

Immune checkpoint inhibitors (ICIs) are most commonly used for melanoma and non-small
cell lung cancer (NSCLC) patients. FAT atypical cadherin 1 (FAT1), which frequently mutates …

Genetic alterations and dysregulation of signaling pathways are indispensable for the
initiation and progression of cancer. Understanding the genetic, molecular, and signaling …

Objective Identifying the drive genes and inhibiting their significant signals were persistently
the main concepts in cancer treatment. However, for oral cavity squamous cell carcinoma …

Tumor initiation represents the first step in tumorigenesis during which normal progenitor
cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo …

Tumor-associated macrophages/microglia (TAMs) are highly plastic and heterogeneous
immune cells that can be immune-supportive or tumor-supportive depending of the …

Abstract Background Blacks/African American (BAA) patients diagnosed with head and neck
squamous cell carcinoma (HNSCC) have worse survival outcomes than White patients …

(1) Background: Head and neck cancer (HNC) ranks as the sixth most prevalent cancer in
the world. In addition to the traditional risk factors such as alcohol and tobacco consumption …

Diagnosing low-grade and high-grade endometrial stromal sarcoma (LG-ESS and HG-ESS)
is a challenge. This study aimed to identify biomarkers. 22 ESS cases were analyzed using …

Simple Summary This phase II, Simon 2-stage, multicenter study evaluated the efficacy of
the combination of CDX-3379 and cetuximab, monoclonal antibodies against ErbB3 and …