The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

Yes‑associated protein (YAP) acts as a transcriptional co‑activator in gene expression and
cell proliferation control by binding to the transcriptional factor TEA domain (TEAD) of the …

Abstract PFKFB3 (6-phosphofructo-2-kinase) is the rate-limiting enzyme of glycolysis and is
overexpressed in several human cancers that are associated with poor prognosis. High …

Women with diminished ovarian reserve (DOR) have reduced fertility, but the underlying
regulation of ovarian function remains unknown. Although differential microRNA (miRNA) …

Mutations in breast cancer type 1 susceptibility protein (BRCA1) and its heterodimeric
binding partner BARD1 confer a high risk for the development of breast and ovarian …

YAP/TAZ transcriptional co‐activators play pivotal roles in tumorigenesis. In the Hippo
pathway, diverse signals activate the MST‐LATS kinase cascade that leads to YAP/TAZ …

Abstract Background Nuclear Yes1‐associated transcriptional regulator (YAP1) promotes
tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its …

Simple Summary BRCA1 has critical functions in accurately repairing double stand breaks
in the DNA through a process known as homologous recombination. BRCA1 also has …

The tumor suppressor BRCA1 accumulates at sites of DNA damage in a ubiquitin‐
dependent manner. In this work, we revisit the role of RAP80 in promoting BRCA1 …

Breast cancer is the most common type of cancer among women worldwide. The Hippo
signaling pathway is strongly associated with cell proliferation, migration, invasion …