Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

Advances in our understanding of how the gut microbiota contributes to human health and
diseases have expanded our insight into how microbial composition and function affect the …

Abstract Purpose of Review With the intention to summarize the currently available evidence
on the pathophysiological relevance of inflammation in heart failure, this review addresses …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

Inflammation is essential in the initial development and progression of many cardiovascular
diseases involving innate and adaptive immune responses. The role of CD4+ CD25+ …

In the past decade, there has been increasing interest in the direct role of MR activation
during pathological remodeling. In severe heart failure, clinical trials have demonstrated that …

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality.
Causes are ill defined but could be through direct cardiac infection and/or inflammation …