Analysis of microRNA functions

C Remsburg, K Konrad, NF Sampilo, JL Song - Methods in Cell Biology, 2019 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that repress the translation and reduce
the stability of target mRNAs in animal cells. Post-transcriptional regulation mediated by …

microRNA-1 regulates sea urchin skeletogenesis by directly targeting skeletogenic genes and modulating components of signaling pathways

NF Sampilo, JL Song - Developmental Biology, 2024 - Elsevier
Abstract microRNAs are evolutionarily conserved non-coding RNAs that direct post-
transcriptional regulation of target transcripts. In vertebrates, microRNA-1 (miR-1) is …

Comparative Analysis of Bivalve and Sea Urchin Genetics and Development: Investigating the Dichotomy in Bilateria

A Drozdov, E Lebedev, L Adonin - International Journal of Molecular …, 2023 - mdpi.com
This comprehensive review presents a comparative analysis of early embryogenesis in
Protostomia and Deuterostomia, the first of which exhibit a mosaic pattern of development …

Primary cilia formation does not rely on WNT/β-catenin signaling

O Bernatik, P Paclikova, A Kotrbova, V Bryja… - Frontiers in Cell and …, 2021 - frontiersin.org
Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They
are instrumental for modulation of several signaling pathways, including Hedgehog, WNT …

[HTML][HTML] microRNA-124 directly suppresses Nodal and Notch to regulate mesodermal development

KD Konrad, M Arnott, M Testa, S Suarez, JL Song - Developmental Biology, 2023 - Elsevier
MicroRNAs regulate gene expression post-transcriptionally by destabilizing and/or inhibiting
translation of target mRNAs in animal cells. MicroRNA-124 (miR-124) has been examined …

An RNA interference approach for functional studies in the sea urchin and its use in analysis of nodal signaling gradients

K Wilson, C Manner, E Miranda, A Berrio, GA Wray… - Developmental …, 2024 - Elsevier
Abstract Dicer substrate interfering RNAs (DsiRNAs) destroy targeted transcripts using the
RNA-Induced Silencing Complex (RISC) through a process called RNA interference (RNAi) …

miR-NPs-RVG promote spinal cord injury repair: implications from spinal cord-derived microvascular endothelial cells

C Li, Z **ang, M Hou, H Yu, P Peng, Y Lv, C Ma… - Journal of …, 2024 - Springer
Background Spinal cord injury (SCI) often leads to a loss of motor and sensory function.
Axon regeneration and outgrowth are key events for functional recovery after spinal cord …

[HTML][HTML] microRNA-31 regulates skeletogenesis by direct suppression of Eve and Wnt1

NF Sampilo, NA Stepicheva, JL Song - Developmental biology, 2021 - Elsevier
Abstract microRNAs (miRNAs) play a critical role in a variety of biological processes,
including embryogenesis and the physiological functions of cells. Evolutionarily conserved …

RNA localization to the mitotic spindle is essential for early development and is regulated by kinesin-1 and dynein

CM Remsburg, KD Konrad… - Journal of Cell …, 2023 - journals.biologists.com
Mitosis is a fundamental and highly regulated process that acts to faithfully segregate
chromosomes into two identical daughter cells. Localization of gene transcripts involved in …

RNA localization to the mitotic spindle regulated by kinesin-1 and dynein is essential for early development of the sea urchin embryo

CM Remsburg, KD Konrad, JL Song - bioRxiv, 2022 - biorxiv.org
Mitosis is a fundamental and highly regulated process that acts to faithfully segregate
chromosomes into two identical daughter cells. Transcript localization of genes involved in …