Multisystem physiological perspective of human frailty and its modulation by physical activity

JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023‏ - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Skeletal muscle performance and ageing

M Tieland, I Trouwborst, BC Clark - Journal of cachexia …, 2018‏ - Wiley Online Library
The world population is ageing rapidly. As society ages, the incidence of physical limitations
is dramatically increasing, which reduces the quality of life and increases healthcare …

Phase angle from bioelectrical impedance analysis is a useful indicator of muscle quality

Y Akamatsu, T Kusakabe, H Arai… - Journal of cachexia …, 2022‏ - Wiley Online Library
Background Methods that facilitate muscle quality measurement may improve the diagnosis
of sarcopenia. Current research has focused on the phase angle (PhA) obtained through …

Sarcopenia and cognitive decline in older adults: targeting the muscle–brain axis

B Arosio, R Calvani, E Ferri, HJ Coelho-Junior… - Nutrients, 2023‏ - mdpi.com
Declines in physical performance and cognition are commonly observed in older adults. The
geroscience paradigm posits that a set of processes and pathways shared among age …

Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta …

E Gielen, D Beckwée, A Delaere… - Nutrition …, 2021‏ - academic.oup.com
Context Sarcopenia is a progressive and generalized skeletal muscle disorder associated
with an increased risk of adverse outcomes such as falls, disability, and death. The Belgian …

Neuromuscular junction formation, aging, and disorders

L Li, WC **ong, L Mei - Annual review of physiology, 2018‏ - annualreviews.org
Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory,
perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed …

Predicting gait adaptations due to ankle plantarflexor muscle weakness and contracture using physics-based musculoskeletal simulations

CF Ong, T Geijtenbeek, JL Hicks… - PLoS computational …, 2019‏ - journals.plos.org
Deficits in the ankle plantarflexor muscles, such as weakness and contracture, occur
commonly in conditions such as cerebral palsy, stroke, muscular dystrophy, Charcot-Marie …

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration

C Elabd, W Cousin, P Upadhyayula, RY Chen… - Nature …, 2014‏ - nature.com
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest
that this process can be reversed by exposure to young circulation; however, systemic age …

Wnt signaling in myogenesis

J von Maltzahn, NC Chang, CF Bentzinger… - Trends in cell …, 2012‏ - cell.com
The formation of skeletal muscle is a tightly regulated process that is critically modulated by
Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple …

Position of the Academy of Nutrition and Dietetics: food and nutrition for older adults: promoting health and wellness

M Bernstein, N Munoz - Journal of the Academy of Nutrition and Dietetics, 2012‏ - Elsevier
It is the position of the Academy of Nutrition and Dietetics that all Americans aged 60 years
and older receive appropriate nutrition care; have access to coordinated, comprehensive …