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Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy
R Du, C Huang, K Liu, X Li, Z Dong - Molecular cancer, 2021 - Springer
Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …
[HTML][HTML] Cyclin dependent kinase-1 (CDK-1) inhibition as a novel therapeutic strategy against pancreatic ductal adenocarcinoma (PDAC)
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal
cancers in humans, due to late diagnosis and limited treatment possibilities. Improved …
cancers in humans, due to late diagnosis and limited treatment possibilities. Improved …
Master kinase PDK1 in tumorigenesis
N Zheng, J Wei, D Wu, Y Xu, J Guo - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
phosphoinositide-dependent protein kinase 1 (PDK1) is considered as master kinase
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …
Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling
Background Platinum-based anticancer drugs have been at the frontline of cancer therapy
for the last 40 years, and are used in more than half of all treatments for different cancer …
for the last 40 years, and are used in more than half of all treatments for different cancer …
Recent updates on oncogenic signaling of aurora kinases in chemosensitive, chemoresistant cancers: novel medicinal chemistry approaches for targeting aurora …
P Kumari, NM Beeraka, A Tengli… - Current Medicinal …, 2024 - benthamdirect.com
The Aurora Kinase family (AKI) is composed of serine-threonine protein kinases involved in
the modulation of the cell cycle and mitosis. These kinases are required for regulating the …
the modulation of the cell cycle and mitosis. These kinases are required for regulating the …
Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile
We report the synthesis of novel first-in-class 2-oxindole-based derivatives as dual PDK1-
AurA kinase inhibitors as a novel strategy to treat Ewing sarcoma. The most potent …
AurA kinase inhibitors as a novel strategy to treat Ewing sarcoma. The most potent …
A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases
N Bhusare, M Kumar - Oncology Research, 2024 - pmc.ncbi.nlm.nih.gov
Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms
of treatment success and patient survival. Current treatment modalities for glioblastoma …
of treatment success and patient survival. Current treatment modalities for glioblastoma …
[HTML][HTML] Targeting MYC to combat pancreatic cancer
YH Liu, YX Gan, JZ Chen, YX Jiang… - Journal of …, 2022 - xiahepublishing.com
Due to its invasiveness, heterogeneity and multiple-drug resistance, pancreatic ductal
adenocarcinoma (PDAC) has been considered as a refractory malignant tumor. Although …
adenocarcinoma (PDAC) has been considered as a refractory malignant tumor. Although …