This contribution is a completely updated and expanded version of the four prior analogous
reviews that were published in this journal in 1997, 2003, 2007, and 2012. In the case of all …

The human genome encodes 538 protein kinases that transfer a γ-phosphate group from
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …

This review is an updated and expanded version of a paper that was published in this
journal in 1997. The time frame has been extended in both directions to include the 22 years …

Protein kinases are targets for treatment of a number of diseases. This review focuses on
kinase inhibitors that are in the clinic or in clinical trials and for which structural information is …

Flavonoids, which are polyphenolic compounds, are a class of plant secondary metabolites
possessing a broad spectrum of pharmacological activity including anti-cancer activities …

Tyrosine kinases are important mediators of the signaling cascade, determining key roles in
diverse biological processes like growth, differentiation, metabolism and apoptosis in …

Many human malignancies are associated with aberrant regulation of protein or lipid
kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein …

Protein kinases constitute one of the largest protein families in humans. 1, 2 The kinase
enzymes in this family catalyze phosphorylation of serine, threonine, or tyrosine residues …

This study was focused on the synthesis of new pyrimidines 4a, b, 5a, b and pyrazoles 6a, b
as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) …

Background & Aims: Resistance is a major challenge in the treatment of patients with
gastrointestinal stromal tumors (GISTs). We investigated the mechanisms of resistance in …