Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental carcinogens and
metabolized by a variety of xenobiotic-metabolizing enzymes such as cytochrome P450 …

The discovery of six distinct polymorphisms in the genetic sequence encoding for the
cytochrome P450 2C9 (CYP2C9) protein has stimulated numerous investigations in an …

Cytochrome P450 is a family of enzymes that catalyze reactions involved in the metabolism
of drugs and other xenobiotics. These enzymes are therefore important in pharmacologic …

The measurement of the effect of new chemical entities on human cytochrome P450 marker
activities using in vitro experimentation represents an important experimental approach in …

The application of pharmacogenetics holds great promise for individualized therapy.
However, it has little clinical reality at present, despite many claims. The main problem is that …

Determination of metabolic properties of a new chemical entity (NCE) is one of the most
important steps during the drug discovery and development process. Nowadays, in vitro …

Cytochrome P450 phenoty** provides valuable information about real-time activity of
these important drug-metabolizing enzymes through the use of specific probe drugs. Despite …