Advancing precision medicine: a review of innovative in silico approaches for drug development, clinical pharmacology and personalized healthcare

L Marques, B Costa, M Pereira, A Silva, J Santos… - Pharmaceutics, 2024 - mdpi.com
The landscape of medical treatments is undergoing a transformative shift. Precision
medicine has ushered in a revolutionary era in healthcare by individualizing diagnostics and …

Epigenetics in health and disease

L Zhang, Q Lu, C Chang - Epigenetics in allergy and autoimmunity, 2020 - Springer
Epigenetic mechanisms, which include DNA methylation, histone modification, and
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …

N6-methyladenine DNA modification in the human genome

CL **ao, S Zhu, M He, D Chen, Q Zhang, Y Chen, G Yu… - Molecular cell, 2018 - cell.com
Summary DNA N 6-methyladenine (6mA) modification is the most prevalent DNA
modification in prokaryotes, but whether it exists in human cells and whether it plays a role in …

[HTML][HTML] DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types

V Constâncio, SP Nunes, R Henrique, C Jerónimo - Cells, 2020 - mdpi.com
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

Targeted therapeutic strategies for triple-negative breast cancer

Y Li, Z Zhan, X Yin, S Fu, X Deng - Frontiers in oncology, 2021 - frontiersin.org
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,
which is characterized by the absence of estrogen receptor (ER) and progesterone receptor …

Pharmacogenomic biomarkers for improved drug therapy—recent progress and future developments

VM Lauschke, L Milani, M Ingelman-Sundberg - The AAPS journal, 2018 - Springer
Much of the inter-individual variability in drug efficacy and risk of adverse reactions is due to
polymorphisms in genes encoding proteins involved in drug pharmacokinetics and …

[KİTAP][B] The handbook of biomarkers

KK Jain, KK Jain - 2010 - Springer
There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

[HTML][HTML] Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications

G Sher, NA Salman, AQ Khan, KS Prabhu… - Seminars in cancer …, 2022 - Elsevier
The global burden of breast cancer (BC) is increasing significantly. This trend is caused by
several factors such as late diagnosis, limited treatment options for certain BC subtypes …

[HTML][HTML] MicroRNAs as biomarkers for diagnosis, prognosis and theranostics in prostate cancer

G Bertoli, C Cava, I Castiglioni - International journal of molecular …, 2016 - mdpi.com
Prostate cancer (PC) includes several phenotypes, from indolent to highly aggressive
cancer. Actual diagnostic and prognostic tools have several limitations, and there is a need …

Anticancer effects of nutraceuticals in the Mediterranean diet: an epigenetic diet model

R Divella, A Daniele, E Savino… - Cancer Genomics & …, 2020 - cgp.iiarjournals.org
Epidemiological and clinical studies support the association between nutrition and
development or progression of different malignancies such as colon, breast, and prostate …