Type I interferons act directly on nociceptors to produce pain sensitization: implications for viral infection-induced pain
One of the first signs of viral infection is body-wide aches and pain. Although this type of pain
usually subsides, at the extreme, viral infections can induce painful neuropathies that can …
usually subsides, at the extreme, viral infections can induce painful neuropathies that can …
RNA‐binding proteins in pain
PR Smith, ZT Campbell - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
RNAs are meticulously controlled by proteins. Through direct and indirect associations,
every facet in the brief life of an mRNA is subject to regulation. R NA‐b inding p roteins …
every facet in the brief life of an mRNA is subject to regulation. R NA‐b inding p roteins …
DNA methylation and non-coding RNAs during tissue-injury associated pain
J Irfan, MR Febrianto, A Sharma, T Rose… - International Journal of …, 2022 - mdpi.com
While about half of the population experience persistent pain associated with tissue
damages during their lifetime, current symptom-based approaches often fail to reduce such …
damages during their lifetime, current symptom-based approaches often fail to reduce such …
Intercellular arc signaling regulates vasodilation
Injury responses require communication between different cell types in the skin. Sensory
neurons contribute to inflammation and can secrete signaling molecules that affect non …
neurons contribute to inflammation and can secrete signaling molecules that affect non …
The RNA-binding protein HuR is integral to the function of nociceptors in mice and humans
HuR is an RNA-binding protein implicated in RNA processing, stability, and translation.
Previously, we examined protein synthesis in dorsal root ganglion (DRG) neurons treated …
Previously, we examined protein synthesis in dorsal root ganglion (DRG) neurons treated …
Global analyses of mRNA expression in human sensory neurons reveal eIF5A as a conserved target for inflammatory pain
Nociceptors are a type of sensory neuron that are integral to most forms of pain. Targeted
disruption of nociceptor sensitization affords unique opportunities to prevent pain. An …
disruption of nociceptor sensitization affords unique opportunities to prevent pain. An …
Inhibition of nonsense-mediated decay induces nociceptive sensitization through activation of the integrated stress response
RNA stability is meticulously controlled. Here, we sought to determine whether an essential
post-transcriptional regulatory mechanism plays a role in pain. Nonsense-mediated decay …
post-transcriptional regulatory mechanism plays a role in pain. Nonsense-mediated decay …
A peptide encoded within a 5′ untranslated region promotes pain sensitization in mice
A peptide encoded within a 5′ untranslated region promotes p... : PAIN A peptide encoded
within a 5′ untranslated region promotes pain sensitization in mice : PAIN International …
within a 5′ untranslated region promotes pain sensitization in mice : PAIN International …
Conserved expression of nav1. 7 and nav1. 8 contribute to the spontaneous and thermally evoked excitability in IL-6 and NGF-sensitized adult dorsal root ganglion …
Sensory neurons respond to noxious stimuli by relaying information from the periphery to the
central nervous system via action potentials driven by voltage-gated sodium channels …
central nervous system via action potentials driven by voltage-gated sodium channels …
Molecular entrapment by RNA: an emerging tool for disrupting protein–RNA interactions in vivo
ABSTRACT mRNA function is controlled by RNA-binding proteins. The specificity of RNA-
binding factors for their targets is critical in that it enables all subsequent regulation. Despite …
binding factors for their targets is critical in that it enables all subsequent regulation. Despite …