Tracing the peopling of the world through genomics
Advances in the sequencing and the analysis of the genomes of both modern and ancient
peoples have facilitated a number of breakthroughs in our understanding of human …
peoples have facilitated a number of breakthroughs in our understanding of human …
Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire
Long-chain polyunsaturated fatty acids (LC-PUFA) are major components of complex lipid
molecules and are also involved in numerous critical biological processes. Studies …
molecules and are also involved in numerous critical biological processes. Studies …
[HTML][HTML] A global reference for human genetic variation
1000 Genomes Project Consortium - Nature, 2015 - ncbi.nlm.nih.gov
Abstract The 1000 Genomes Project set out to provide a comprehensive description of
common human genetic variation by applying whole-genome sequencing to a diverse set of …
common human genetic variation by applying whole-genome sequencing to a diverse set of …
Genome-wide patterns of selection in 230 ancient Eurasians
Ancient DNA makes it possible to observe natural selection directly by analysing samples
from populations before, during and after adaptation events. Here we report a genome-wide …
from populations before, during and after adaptation events. Here we report a genome-wide …
Recurrent evolution and selection shape structural diversity at the amylase locus
The adoption of agriculture triggered a rapid shift towards starch-rich diets in human
populations. Amylase genes facilitate starch digestion, and increased amylase copy number …
populations. Amylase genes facilitate starch digestion, and increased amylase copy number …
Genomic analyses from non-invasive prenatal testing reveal genetic associations, patterns of viral infections, and Chinese population history
We analyze whole-genome sequencing data from 141,431 Chinese women generated for
non-invasive prenatal testing (NIPT). We use these data to characterize the population …
non-invasive prenatal testing (NIPT). We use these data to characterize the population …
Harnessing ancient genomes to study the history of human adaptation
The past several years have witnessed an explosion of successful ancient human genome-
sequencing projects, with genomic-scale ancient DNA data sets now available for more than …
sequencing projects, with genomic-scale ancient DNA data sets now available for more than …
The evolution of the human trophic level during the Pleistocene
M Ben‐Dor, R Sirtoli, R Barkai - American journal of physical …, 2021 - Wiley Online Library
The human trophic level (HTL) during the Pleistocene and its degree of variability serve,
explicitly or tacitly, as the basis of many explanations for human evolution, behavior, and …
explicitly or tacitly, as the basis of many explanations for human evolution, behavior, and …
FADS1 and the Timing of Human Adaptation to Agriculture
Variation at the FADS1/FADS2 gene cluster is functionally associated with differences in
lipid metabolism and is often hypothesized to reflect adaptation to an agricultural diet. Here …
lipid metabolism and is often hypothesized to reflect adaptation to an agricultural diet. Here …
FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health
B Koletzko, E Reischl, C Tanjung… - Annual review of …, 2019 - annualreviews.org
Variants in the FADS gene cluster modify the activity of polyunsaturated fatty acid (PUFA)
desaturation and the lipid composition in human blood and tissue. FADS variants have been …
desaturation and the lipid composition in human blood and tissue. FADS variants have been …