Sex differences in neural mechanisms mediating reward and addiction
There is increasing evidence in humans and laboratory animals for biologically based sex
differences in every phase of drug addiction: acute reinforcing effects, transition from …
differences in every phase of drug addiction: acute reinforcing effects, transition from …
Addiction and stress: An allostatic view
Allostasis, or stability through change, has most often been linked with challenges to
homeostasis, in which repeated challenges or stressors produce sufficient allostatic load to …
homeostasis, in which repeated challenges or stressors produce sufficient allostatic load to …
The novel object recognition memory: neurobiology, test procedure, and its modifications
M Antunes, G Biala - Cognitive processing, 2012 - Springer
Animal models of memory have been considered as the subject of many scientific
publications at least since the beginning of the twentieth century. In humans, memory is …
publications at least since the beginning of the twentieth century. In humans, memory is …
The development and maintenance of drug addiction
What is the defining property of addiction? We dust off a several-decades-long debate about
the relative importance of two forms of reinforcement—positive reinforcement, subjectively …
the relative importance of two forms of reinforcement—positive reinforcement, subjectively …
The dark side of emotion: the addiction perspective
GF Koob - European journal of pharmacology, 2015 - Elsevier
Emotions are “feeling” states and classic physiological emotive responses that are
interpreted based on the history of the organism and the context. Motivation is a persistent …
interpreted based on the history of the organism and the context. Motivation is a persistent …
Addiction as a stress surfeit disorder
Drug addiction has been conceptualized as a chronically relapsing disorder of compulsive
drug seeking and taking that progresses through three stages: binge/intoxication …
drug seeking and taking that progresses through three stages: binge/intoxication …
Addiction is a reward deficit and stress surfeit disorder
GF Koob - Frontiers in psychiatry, 2013 - frontiersin.org
Drug addiction can be defined by a three-stage cycle–binge/intoxication,
withdrawal/negative affect, and preoccupation/anticipation–that involves allostatic changes …
withdrawal/negative affect, and preoccupation/anticipation–that involves allostatic changes …
Suicide risk and addiction: the impact of alcohol and opioid use disorders
Abstract Purpose of Review Suicide is a major public health concern and a leading cause of
death in the US. Alcohol and opioid use disorders (AUD/OUD) significantly increase risk for …
death in the US. Alcohol and opioid use disorders (AUD/OUD) significantly increase risk for …
Negative reinforcement in drug addiction: the darkness within
GF Koob - Current opinion in neurobiology, 2013 - Elsevier
Highlights•Drug seeking is associated with reward neural circuitry activation.•Addiction
involves decreased brain reward and recruitment of brain stress systems.•The …
involves decreased brain reward and recruitment of brain stress systems.•The …
The role of NFkB in drug addiction: beyond inflammation
Aims Nuclear factor kappa light chain enhancer of activated B cells (NFkB) is a ubiquitous
transcription factor well known for its role in the innate immune response. As such, NFkB is a …
transcription factor well known for its role in the innate immune response. As such, NFkB is a …