Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

The receptor for advanced glycation end products (RAGE) is a non-specific multi-ligand
pattern recognition receptor capable of binding to a range of structurally diverse ligands …

A key unknown of the functional space in tumor immunity is whether CD4 T cells depend on
intratumoral MHCII cancer antigen recognition. MHCII-expressing, antigen-presenting …

Although the complement system is primarily perceived as a host defence system, a more
versatile, yet potentially more harmful side of this innate immune pathway as an …

Secondary lymphoid tissues share the important function of bringing together antigens and
rare antigen‐specific lymphocytes to foster induction of adaptive immune responses. Peyer's …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

The main features of the triple helical structure of collagen were deduced in the mid-1950s
from fibre X-ray diffraction of tendons. Yet, the resulting models only could offer an average …

Complement C1q is the activator of the classical pathway. However, it is now recognized
that C1q can exert functions unrelated to complement activation. Here we show that C1q, but …

Originally discovered as part of C1, the initiation component of the classical complement
pathway, it is now appreciated that C1q regulates a variety of cellular processes …