An evolutionary perspective on field cancerization
Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …
even before any of the usual morphological correlates of pre-malignancy are recognizable …
[HTML][HTML] Classifying the evolutionary and ecological features of neoplasms
Neoplasms change over time through a process of cell-level evolution, driven by genetic
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …
The evolutionary history of lethal metastatic prostate cancer
Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple
competing subclones within a single primary tumour,,,. This evolutionary process culminates …
competing subclones within a single primary tumour,,,. This evolutionary process culminates …
Clonal evolution in cancer
M Greaves, CC Maley - Nature, 2012 - nature.com
Cancers evolve by a reiterative process of clonal expansion, genetic diversification and
clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are …
clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are …
Paired exome analysis of Barrett's esophagus and adenocarcinoma
Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) through a
stepwise progression with loss of CDKN2A followed by TP53 inactivation and aneuploidy …
stepwise progression with loss of CDKN2A followed by TP53 inactivation and aneuploidy …
Cancer genes and the pathways they control
The revolution in cancer research can be summed up in a single sentence: cancer is, in
essence, a genetic disease. In the last decade, many important genes responsible for the …
essence, a genetic disease. In the last decade, many important genes responsible for the …
Cancer as an evolutionary and ecological process
Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells
compete for space and resources, evade predation by the immune system and can even …
compete for space and resources, evade predation by the immune system and can even …
Accumulation of driver and passenger mutations during tumor progression
Major efforts to sequence cancer genomes are now occurring throughout the world. Though
the emerging data from these studies are illuminating, their reconciliation with epidemiologic …
the emerging data from these studies are illuminating, their reconciliation with epidemiologic …
Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma
The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its
precursor lesion, Barrett's esophagus, is poorly understood. Using whole-genome …
precursor lesion, Barrett's esophagus, is poorly understood. Using whole-genome …
Evolution and progression of Barrett's oesophagus to oesophageal cancer
Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection
and population expansion. Early steps in this process are driven by a set of mutated driver …
and population expansion. Early steps in this process are driven by a set of mutated driver …