Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in
diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are …

Although differential transcription drives the development of multicellular organisms, the
ultimate readout of a protein-coding gene is ribosome-dependent mRNA translation …

The ability of ribosomes to translate mRNAs into proteins is the basis of all life. While
ribosomes are essential for cell viability, reduction in levels of ribosomes can affect cell fate …

The tight control of fate transitions during stem cell differentiation is essential for proper
tissue development and maintenance. However, the challenges in studying sparsely …

During development of the human cerebral cortex, multipotent neural progenitors generate
excitatory neurons and glial cells. Investigations of the transcriptome and epigenome have …

Long-term overuse of chemical nematicides has resulted in low control efficacy toward
destructive root-knot nematodes, and continuous development in nanotechnology is …

Preserving a large number of essential yet highly unstable ribosomal DNA (rDNA) repeats is
critical for the germline to perpetuate the genome through generations. Spontaneous rDNA …

Ribosomal proteins (RPs) constitute the ribosome, thus participating in the protein
biosynthesis process. Emerging studies have suggested that many RPs exhibit different …

In this chapter, we highlight examples of the diverse array of developmental, cellular, and
biochemical insights that can be gained by using Drosophila melanogaster oogenesis as a …

Stem cells in many systems, including Drosophila germline stem cells (GSCs), increase
ribosome biogenesis and translation during terminal differentiation. Here, we show that the …