Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound
multiorgan effects. The low prevalence of SCD (∼ 100,000/US) has limited progress in …

Design. This is a structured evidence-based review of all available studies on the
development of abuse/addiction and aberrant drug-related behaviors (ADRBs) in chronic …

BACKGROUND: The intersection of pain, addiction and mental health has not been
adequately described. We describe the roles of these three conditions in a chronic pain …

The Prescription Drug Use Questionnaire (PDUQ) is one of several published tools
developed to help clinicians better identify the presence of opioid abuse or dependence in …

Background Given the growing worldwide market of non-prescription drugs, monitoring their
misuse in the context of self-medication represents a particular challenge in Public Health …

OBJECTIVE: Identify the risk factors for prescription opioid misuse among patients taking
prescription opioids to deal with chronic pain. METHODS: We examined the literature for a …

Tremendous growth in opioid prescribing over two decades in the USA has correlated with
proportional increases in diversion, addiction, and overdose deaths. Pseudoaddiction, a …

A clinical conundrum can occur when a patient with active opioid use disorder (OUD) or at
elevated risk for the condition presents with cancer and related painful symptoms. Despite …

Objective. We sought to investigate the association between chronic pain and self-reported
prescription drug abuse in a large cohort of patients referred from primary care for a …

Objective. Pain has a critical role in the management of sickle cell disease (SCD). Patients
may suffer from several pain syndromes, which may be or not may be associated with other …