The pathogenesis of Legionella pneumophila is derived from its growth within lung
macrophages after aerosols are inhaled from contaminated water sources. Interest in this …

Type-IV secretion systems are devices present in a wide range of bacteria (including
bacterial pathogens) that deliver macromolecules (proteins and single-strand-DNA) across …

Signalling by ubiquitination regulates virtually every cellular process in eukaryotes. Covalent
attachment of ubiquitin to a substrate is catalysed by the E1, E2 and E3 three-enzyme …

The genus Legionella comprises 65 species, among which Legionella pneumophila is a
human pathogen causing severe pneumonia. To understand the evolution of an …

Legionella pneumophila is an intracellular pathogen that multiplies in a specialized vacuole
within host cells. Biogenesis of this vacuole requires the Dot/Icm type IV protein translocation …

The intracellular pathogen Legionella pneumophila replicates in a vacuole that recruits
material from the host cell endoplasmic reticulum (ER). Biogenesis of this unique vacuole …

Legionella pneumophila is an intracellular pathogen responsible for Legionnaires' disease.
This bacterium uses the Dot/Icm type IV secretion system to inject a large number of …

Legionella pneumophila replicates inside alveolar macrophages and causes an acute,
potentially fatal pneumonia called Legionnaires' disease. The ability of this bacterium to …

Type IV secretion systems (T4SSs) play a central role in the pathogenicity of many important
pathogens, including Agrobacterium tumefaciens, Helicobacter pylori, and Legionella …

Legionella pneumophila establishes a replication vacuole within phagocytes that requires
the bacterial Dot/Icm apparatus for its formation. This apparatus is predicted to translocate …