Pathogenesis and virulence of herpes simplex virus
S Zhu, A Viejo-Borbolla - Virulence, 2021 - Taylor & Francis
Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
The race between host antiviral innate immunity and the immune evasion strategies of herpes simplex virus 1
H Zhu, C Zheng - Microbiology and Molecular Biology Reviews, 2020 - Am Soc Microbiol
SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …
Selective autophagy and xenophagy in infection and disease
Autophagy, a cellular homeostatic process, which ensures cellular survival under various
stress conditions, has catapulted to the forefront of innate defense mechanisms during …
stress conditions, has catapulted to the forefront of innate defense mechanisms during …
Differential roles of interferons in innate responses to mucosal viral infections
Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral
infection and are crucial for control of viral replication and dissemination, especially at …
infection and are crucial for control of viral replication and dissemination, especially at …
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing
A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …
receptor (PRR)-initiated immune responses is required to achieve the most favorable …
Inhibition of cGAS DNA sensing by a herpesvirus virion protein
Invading viral DNA can be recognized by the host cytosolic DNA sensor, cyclic GMP-AMP
(cGAMP) synthase (cGAS), resulting in production of the second messenger cGAMP, which …
(cGAMP) synthase (cGAS), resulting in production of the second messenger cGAMP, which …
Herpes simplex virus evasion of early host antiviral responses
EI Tognarelli, TF Palomino, N Corrales… - Frontiers in cellular …, 2019 - frontiersin.org
Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for
thousands of years and are present at a high prevalence in the population worldwide. HSV …
thousands of years and are present at a high prevalence in the population worldwide. HSV …
Evasion of host antiviral innate immunity by HSV-1, an update
C Su, G Zhan, C Zheng - Virology journal, 2016 - Springer
Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate
immune responses. The type I interferon (IFN) signal pathway is a central aspect of host …
immune responses. The type I interferon (IFN) signal pathway is a central aspect of host …
Ubiquitin in the activation and attenuation of innate antiviral immunity
Viral infection activates danger signals that are transmitted via the retinoic acid–inducible
gene 1–like receptor (RLR), nucleotide-binding oligomerization domain-like receptor (NLR) …
gene 1–like receptor (RLR), nucleotide-binding oligomerization domain-like receptor (NLR) …
Herpes simplex virus type 1 interactions with the interferon system
K Danastas, M Miranda-Saksena… - International journal of …, 2020 - mdpi.com
The interferon (IFN) system is one of the first lines of defense activated against invading viral
pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of …
pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of …