The cGAS–STING pathway and cancer
N Samson, A Ablasser - Nature cancer, 2022 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
Cellular functions of cGAS-STING signaling
C Chen, P Xu - Trends in cell biology, 2023 - cell.com
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
The cGAS–STING pathway as a therapeutic target in inflammatory diseases
A Decout, JD Katz, S Venkatraman… - Nature Reviews …, 2021 - nature.com
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
Stimulator of interferon genes (STING) is essential for the type I interferon response against
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …
Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
Role of the cGAS–STING pathway in systemic and organ-specific diseases
Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
Molecular mechanisms and cellular functions of cGAS–STING signalling
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
Structures and mechanisms in the cGAS-STING innate immunity pathway
Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
L Zhang, C Jiang, Y Zhong, K Sun, H **g, J Song… - Nature Cell …, 2023 - nature.com
Evasion of antitumour immunity is a hallmark of cancer. STING, a putative innate immune
signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating …
signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating …