Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the
polymerization of actin to produce stress fibers and lamellipodia, respectively. We report …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in
diverse organisms. Here we review findings from budding and fission yeasts that reveal both …

The initial discovery that ras genes endowed retroviruses with potent carcinogenic
properties and the subsequent determination that mutated ras genes were present in a wide …

We have identified two components of a new protein kinase signaling cascade, MAPK/ERK
kinase 5 (MEK5) and extracellular signal-regulated kinase 5 (ERK5). The MEK5 cDNA was …

GTPases of the Ras superfamily act as molecular switches to control a wide range of
essential biochemical pathways in all eukaryotic cells. Among the 60 or so that have been …

Many cells are able to orient themselves in a non-uniform environment by responding to
localized cues. This leads to a polarized cellular response, where the cell can either grow or …