The authors were asked by the Editors of ACS Chemical Biology to write an article titled
“Why Nature Chose Selenium” for the occasion of the upcoming bicentennial of the …

Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Selenium is an essential micronutrient in diverse organisms. Two routes are known for its
insertion into proteins and nucleic acids, via selenocysteine and 2-selenouridine …

The goal of this review is to place the exciting advances that have occurred in our
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …

▪ Abstract Aminoacyl-tRNAs are substrates for translation and are pivotal in determining how
the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is …

The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …

1. The Fundamental Alternatives 2. The First Energy Source for Life (a) Exergonic pyrite
formation (b) The requirement of redox inhibition 3. Pyrite-Surface Bonding 4. Surface …

Great excitement was elicited in the field of selenium biochemistry in 1986 by the parallel
discoveries that the genes encoding the selenoproteins glutathione peroxidase and …

Selenocysteine is recognized as the 21st amino acid in ribosome-mediated protein
synthesis and its specific incorporation is directed by the UGA codon. Unique tRNAs that …

Selenium species, particularly the oxyanions selenite (SeO3 2−) and selenate (SeO4 2−),
are significant pollutants in the environment that leach from rocks and are released by …