Kisspeptins and reproduction: physiological roles and regulatory mechanisms
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …
have evolved to mediate the diverse internal and external environmental inputs that regulate …
Kisspeptin signaling in the brain
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III
The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of
this peptide is currently under investigation. Here, we identified SPX along with a second …
this peptide is currently under investigation. Here, we identified SPX along with a second …
The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies
The kiss1/gpr54 signaling system is considered to be a critical regulator of reproduction in
most vertebrates. However, this presumption has not been tested vigorously in …
most vertebrates. However, this presumption has not been tested vigorously in …
Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish
A Servili, Y Le Page, J Leprince, A Caraty… - …, 2011 - academic.oup.com
Kisspeptins are new actors in the neuroendocrine regulation of reproduction. In vertebrates,
the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 …
the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 …
Discovery and evolutionary history of gonadotrophin‐inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction
Gonadotrophin‐releasing hormone (GnRH) is the primary hypothalamic factor responsible
for the control of gonadotrophin secretion in vertebrates. However, within the last decade …
for the control of gonadotrophin secretion in vertebrates. However, within the last decade …
Role of serotonin in fish reproduction
The neuroendocrine mechanism regulates reproduction through the hypothalamo-pituitary-
gonadal (HPG) axis which is evolutionarily conserved in vertebrates. The HPG axis is …
gonadal (HPG) axis which is evolutionarily conserved in vertebrates. The HPG axis is …
KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers?
Present therapeutic approaches do not effectively target metastatic cancers, often limited by
their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy …
their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy …
Comparative insights of the kisspeptin/kisspeptin receptor system: lessons from non-mammalian vertebrates
Kisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as
ligands of the G protein-coupled receptor 54 (GPR54; also termed Kiss1R) with ability to …
ligands of the G protein-coupled receptor 54 (GPR54; also termed Kiss1R) with ability to …
Direct and indirect effects of sex steroids on gonadotrope cell plasticity in the teleost fish pituitary
The pituitary gland controls many important physiological processes in vertebrates,
including growth, homeostasis, and reproduction. As in mammals, the teleost pituitary …
including growth, homeostasis, and reproduction. As in mammals, the teleost pituitary …