Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

Epidemiological studies have provided evidence that traffic noise exposure is linked to
cardiovascular diseases such as arterial hypertension, myocardial infarction, and stroke …

A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a
cascade of intracellular components that mediate its effects, plays a major role in the …

Aims Epidemiological studies indicate that traffic noise increases the incidence of coronary
artery disease, hypertension and stroke. The underlying mechanisms remain largely …

In the present paper, we describe multiple levels of cross-talk between the PI3K
(phosphoinositide 3-kinase)/Akt and Ras/MAPK (mitogen-activated protein kinase) …

Hepatocellular carcinoma (HCC), a common liver malignancy worldwide, has high morbidity
and mortality. β-Thujaplicin, a tropolone derivative, has been used in some health-care …

Dengue virus (DENV), an emerging mosquito-transmitted pathogen capable of causing
severe disease in humans, interacts with host cell factors to create a more favorable …

The mood disorders major depressive disorder and bipolar disorder are prevalent, are
inadequately treated, and little is known about their etiologies. A better understanding of the …

Omics technologies emerged as complementary strategies to genomics in the attempt to
understand human illnesses. In general, proteomics technologies emerged earlier than …

Non-invasively evaluating gene expression products in human pre-implantation embryos
remains a significant challenge. Here, we develop a non-invasive method for …