Protein kinase CK2 ('casein kinase II') has traditionally been classified as a messenger-
independent protein serine/threonine kinase that is typically found in tetrameric complexes …

Protein kinase CK2 is a pleiotropic, ubiquitous and constitutively active protein kinase that
can use both ATP and GTP as phosphoryl donors with specificity for serine/threonine …

Physiological anti-inflammatory mechanisms can potentially be exploited for the treatment of
inflammatory disorders. Here we report that the neurotransmitter acetylcholine inhibits …

The tumor suppressor phosphatase PTEN regulates cell migration, growth, and survival by
dephosphorylating phosphatidylinositol second messengers and signaling …

Programmed death 1 (PD-1) is a potent inhibitor of T cell responses. PD-1 abrogates
activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, but the mechanism …

Tau and MAP1B are the main members of neuronal microtubule-associated proteins
(MAPs), the functions of which have remained obscure because of a putative functional …

Fragile X mental retardation protein, FMRP, is absent in patients with fragile X syndrome, a
common form of mental retardation. FMRP is a nucleocytoplasmic RNA binding protein that …

MAP1B and MAP2 are major members of neuronal microtubule-associated proteins (MAPs).
To gain insights into the function of MAP2 in vivo, we generated MAP2-deficient (map 2−/−) …

More than 46 years ago, Burnett and Kennedy first described protein kinase CK2 (formerly
known as casein kinase 2) in liver extracts. Since then, protein kinase CK2 has been …

We have recently shown that glycogen synthase kinase 3β (GSK3β) phosphorylates the
microtubule-associated protein (MAP) 1B in an in vitro kinase assay and in cultured …