Manganese (Mn) is an important micronutrient for plant growth and development and
sustains metabolic roles within different plant cell compartments. The metal is an essential …

Many trace metals are essential micronutrients, but also potent toxins. Due to natural and
anthropogenic causes, vastly different trace metal concentrations occur in various habitats …

Although the genes essential for life have been identified in less complex model organisms,
their elucidation in human cells has been hindered by technical barriers. We used extensive …

Large-scale genetic analysis of lethal phenotypes has elucidated the molecular
underpinnings of many biological processes. Using the bacterial clustered regularly …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Over 100 human genetic disorders result from mutations in glycosylation-related genes. In
2013, a new glycosylation disorder was reported every 17 days. This trend will probably …

Lysosomal calcium (Ca2+) release is critical to cell signaling and is mediated by well-known
lysosomal Ca2+ channels. Yet, how lysosomes refill their Ca2+ remains hitherto …

Abstract Calcium (Ca2+) and manganese (Mn2+) are essential elements for plants and have
similar ionic radii and binding coordination. They are assigned specific functions within …

Glycosylation is a ubiquitous modification of lipids and proteins. Despite the essential
contribution of glycoconjugates to the viability of all living organisms, diseases of …

In plants, algae, and cyanobacteria, photosystem II (PSII) catalyzes the light-driven oxidation
of water. The oxygen-evolving complex of PSII is a Mn4CaO5 cluster embedded in a well …