Lipoprotein (a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement

F Kronenberg, S Mora, ESG Stroes… - European heart …, 2022 - academic.oup.com
Abstract This 2022 European Atherosclerosis Society lipoprotein (a)[Lp (a)] consensus
statement updates evidence for the role of Lp (a) in atherosclerotic cardiovascular disease …

A test in context: lipoprotein (a) diagnosis, prognosis, controversies, and emerging therapies

S Tsimikas - Journal of the American College of Cardiology, 2017 - jacc.org
Evidence that elevated lipoprotein (a)(Lp [a]) levels contribute to cardiovascular disease
(CVD) and calcific aortic valve stenosis (CAVS) is substantial. Development of isoform …

[HTML][HTML] Lipoprotein (a) reduction in persons with cardiovascular disease

S Tsimikas, E Karwatowska-Prokopczuk… - … England Journal of …, 2020 - Mass Medical Soc
Background Lipoprotein (a) levels are genetically determined and, when elevated, are a risk
factor for cardiovascular disease and aortic stenosis. There are no approved pharmacologic …

Baseline and on-statin treatment lipoprotein (a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials

P Willeit, PM Ridker, PJ Nestel, J Simes, AM Tonkin… - The Lancet, 2018 - thelancet.com
Background Elevated lipoprotein (a) is a genetic risk factor for cardiovascular disease in
general population studies. However, its contribution to risk for cardiovascular events in …

Oxidized phospholipids on lipoprotein (a) elicit arterial wall inflammation and an inflammatory monocyte response in humans

FM van der Valk, S Bekkering, J Kroon, C Yeang… - Circulation, 2016 - ahajournals.org
Background: Elevated lipoprotein (a)[Lp (a)] is a prevalent, independent cardiovascular risk
factor, but the underlying mechanisms responsible for its pathogenicity are poorly defined …

[HTML][HTML] Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - Elsevier
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

NHLBI working group recommendations to reduce lipoprotein (a)-mediated risk of cardiovascular disease and aortic stenosis

S Tsimikas, S Fazio, KC Ferdinand… - Journal of the American …, 2018 - jacc.org
Pathophysiological, epidemiological, and genetic studies provide strong evidence that
lipoprotein (a)[Lp (a)] is a causal mediator of cardiovascular disease (CVD) and calcific …

Lipoprotein (a) in atherosclerotic diseases: from pathophysiology to diagnosis and treatment

S Lampsas, M Xenou, E Oikonomou, P Pantelidis… - Molecules, 2023 - mdpi.com
Lipoprotein (a)(Lp (a)) is a low-density lipoprotein (LDL) cholesterol-like particle bound to
apolipoprotein (a). Increased Lp (a) levels are an independent, heritable causal risk factor …

Effect of pelacarsen on lipoprotein (a) cholesterol and corrected low-density lipoprotein cholesterol

C Yeang, E Karwatowska-Prokopczuk, F Su… - Journal of the American …, 2022 - jacc.org
Background Laboratory methods that report low-density lipoprotein cholesterol (LDL-C)
include both LDL-C and lipoprotein (a) cholesterol [Lp (a)-C] content. Objectives The …

Antisense therapy targeting apolipoprotein (a): a randomised, double-blind, placebo-controlled phase 1 study

S Tsimikas, NJ Viney, SG Hughes, W Singleton… - The Lancet, 2015 - thelancet.com
Summary Background Lipoprotein (a)(Lp [a]) is a risk factor for cardiovascular disease and
calcific aortic valve stenosis. No effective therapies to lower plasma Lp (a) concentrations …