Integrative approaches for finding modular structure in biological networks
A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …
the cell. To this end, large and complex networks of molecular interactions are being rapidly …
Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms
T Van Opijnen, A Camilli - Nature Reviews Microbiology, 2013 - nature.com
Our knowledge of gene function has increasingly lagged behind gene discovery, hindering
our understanding of the genetic basis of microbial phenotypes. Recently, however …
our understanding of the genetic basis of microbial phenotypes. Recently, however …
Systems-level analysis of mechanisms regulating yeast metabolic flux
INTRODUCTION Metabolism is among the most strongly conserved processes across all
domains of life and is crucial for both bioengineering and disease research, yet we still have …
domains of life and is crucial for both bioengineering and disease research, yet we still have …
[HTML][HTML] Phenotypic landscape of a bacterial cell
The explosion of sequence information in bacteria makes develo** high-throughput, cost-
effective approaches to matching genes with phenotypes imperative. Using E. coli as proof …
effective approaches to matching genes with phenotypes imperative. Using E. coli as proof …
Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms
T Van Opijnen, KL Bodi, A Camilli - Nature methods, 2009 - nature.com
Biological pathways are structured in complex networks of interacting genes. Solving the
architecture of such networks may provide valuable information, such as how …
architecture of such networks may provide valuable information, such as how …
MAP kinase signalling cascades and transcriptional regulation
The MAP kinase (MAPK) signalling pathways play fundamental roles in a wide range of
cellular processes and are often deregulated in disease states. One major mode of action for …
cellular processes and are often deregulated in disease states. One major mode of action for …
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria
S Hoppins, SR Collins, A Cassidy-Stone… - Journal of Cell …, 2011 - rupress.org
To broadly explore mitochondrial structure and function as well as the communication of
mitochondria with other cellular pathways, we constructed a quantitative, high-density …
mitochondria with other cellular pathways, we constructed a quantitative, high-density …
The recurrent architecture of tumour initiation, progression and drug sensitivity
Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …
architecture in which genomic alterations cluster upstream of functional master regulator …
[HTML][HTML] Synthetic lethality: general principles, utility and detection using genetic screens in human cells
SMB Nijman - FEBS letters, 2011 - Elsevier
Synthetic lethality occurs when the simultaneous perturbation of two genes results in cellular
or organismal death. Synthetic lethality also occurs between genes and small molecules …
or organismal death. Synthetic lethality also occurs between genes and small molecules …
An overview of Cdk1-controlled targets and processes
The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …
model organism S. cerevisiae. Research performed during the past decade has significantly …