Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging

ACT Ng, V Delgado, BA Borlaug, JJ Bax - Nature Reviews Cardiology, 2021 - nature.com
Diabesity is a term used to describe the combined adverse health effects of obesity and
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …

Pharmacotherapy of type 2 diabetes: an update

J Upadhyay, SA Polyzos, N Perakakis, B Thakkar… - Metabolism, 2018 - Elsevier
Abstract Type 2 diabetes (T2DM) is a leading cause of morbidity and mortality worldwide
and a major economic burden. The prevalence of T2DM is rising, suggesting more effective …

GLP-1RAs in type 2 diabetes: mechanisms that underlie cardiovascular effects and overview of cardiovascular outcome data

AC Sposito, O Berwanger, LSF de Carvalho… - Cardiovascular …, 2018 - Springer
Patients with type 2 diabetes (T2DM) have a substantial risk of develo** cardiovascular
disease. The strong connection between the severity of hyperglycaemia, metabolic changes …

Cardiac autonomic neuropathy in diabetes: a predictor of cardiometabolic events

AI Vinik, C Casellini, HK Parson, SR Colberg… - Frontiers in …, 2018 - frontiersin.org
Autonomic nervous system (ANS) imbalance manifesting as cardiac autonomic neuropathy
in the diabetic population is an important predictor of cardiovascular events. Symptoms and …

Differential effects of glucagon-like peptide-1 receptor agonists on heart rate

M Lorenz, F Lawson, D Owens, D Raccah… - Cardiovascular …, 2017 - Springer
While glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are known to increase heart
rate (HR), it is insufficiently recognized that the extent varies greatly between the various …

Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node

AF Lubberding, S Veedfald, JS Achter… - Cardiovascular …, 2024 - academic.oup.com
Aims Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used to treat
type 2 diabetes and obesity. Albeit cardiovascular outcomes generally improve, treatment …

Glucagon‐like peptide‐1 receptor agonists modestly reduced blood pressure among patients with and without diabetes mellitus: a meta‐analysis and meta …

FB Rivera, GNO Lumbang, DRM Gaid… - Diabetes, Obesity …, 2024 - Wiley Online Library
Aim The cardiovascular benefits provided by glucagon‐like peptide‐1 receptor agonists
(GLP‐1RAs) extend beyond weight reduction and glycaemic control. One possible …

Effects of 6-month treatment with the glucagon like peptide-1 analogue liraglutide on arterial stiffness, left ventricular myocardial deformation and oxidative stress in …

V Lambadiari, G Pavlidis, F Kousathana… - Cardiovascular …, 2018 - Springer
Background Incretin-based therapies are used in the treatment of type 2 diabetes mellitus
(T2DM) and obesity. We investigated the changes in arterial stiffness and left ventricular (LV) …

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis

R Bruen, S Curley, S Kajani, D Crean… - Cardiovascular …, 2017 - Springer
Background Macrophages play a pivotal role in atherosclerotic plaque development. Recent
evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide …

How do SGLT2 (sodium-glucose cotransporter 2) inhibitors and GLP-1 (glucagon-like peptide-1) receptor agonists reduce cardiovascular outcomes? Completed and …

MMY Lee, MC Petrie, JJV McMurray… - … , and vascular biology, 2020 - ahajournals.org
Objective: There is substantial interest in how GLP-1RA (glucagon-like peptide-1 receptor
agonists) and SGLT2 (sodium-glucose cotransporter 2) inhibitors reduce cardiovascular and …