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Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential
N Wu, W Zheng, Y Zhou, Y Tian, M Tang, X Feng… - Ageing Research …, 2024 - Elsevier
Macroautophagy/autophagy is primarily accountable for the degradation of damaged
organelles and toxic macromolecules in the cells. Regarding the essential function of …
organelles and toxic macromolecules in the cells. Regarding the essential function of …
[HTML][HTML] MicroRNA as a potential therapeutic molecule in cancer
Small noncoding RNAs, as post-translational regulators of many target genes, are not only
markers of neoplastic disease initiation and progression, but also markers of response to …
markers of neoplastic disease initiation and progression, but also markers of response to …
Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches
Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer.
Although there are different treatment options, these strategies are not efficient in terms of …
Although there are different treatment options, these strategies are not efficient in terms of …
Targeting mTOR for anti-aging and anti-cancer therapy
W Fu, G Wu - Molecules, 2023 - mdpi.com
The balance between anabolism and catabolism is disrupted with aging, with the rate of
anabolism being faster than that of catabolism. Therefore, mTOR, whose major function is to …
anabolism being faster than that of catabolism. Therefore, mTOR, whose major function is to …
Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells
Transfection of tumor suppressor miRNAs such as miR-34a, miR-449a, and miR-16 with
DNA damage can regulate apoptosis and senescence in cancer cells. miR-16 has been …
DNA damage can regulate apoptosis and senescence in cancer cells. miR-16 has been …
[HTML][HTML] LncRNA PTENP1/miR-21/PTEN axis modulates EMT and drug resistance in cancer: dynamic boolean modeling for cell fates in DNA damage response
S Gupta, DA Silveira, PR Lorenzoni… - International journal of …, 2024 - mdpi.com
It is well established that microRNA-21 (miR-21) targets phosphatase and tensin homolog
(PTEN), facilitating epithelial-to-mesenchymal transition (EMT) and drug resistance in …
(PTEN), facilitating epithelial-to-mesenchymal transition (EMT) and drug resistance in …
[HTML][HTML] A dynamic Boolean network reveals that the BMI1 and MALAT1 axis is associated with drug resistance by limiting miR-145-5p in non-small cell lung cancer
S Gupta, DA Silveira, GPS Piedade… - Non-coding RNA …, 2024 - Elsevier
Patients with non-small cell lung cancer (NSCLC) are often treated with chemotherapy. Poor
clinical response and the onset of chemoresistance limit the anti-tumor benefits of drugs …
clinical response and the onset of chemoresistance limit the anti-tumor benefits of drugs …
[HTML][HTML] In Vitro Cell Death Mechanisms Induced by Dicoma anomala Root Extract in Combination with ZnPcS4 Mediated-Photodynamic Therapy in A549 Lung …
Globally, lung cancer has remained the leading cause of morbidity and mortality in men and
women. To enhance photodynamic therapeutic effects in vitro, the present study was …
women. To enhance photodynamic therapeutic effects in vitro, the present study was …
Network analysis reveals that the tumor suppressor lncRNA GAS5 acts as a double-edged sword in response to DNA damage in gastric cancer
The lncRNA GAS5 acts as a tumor suppressor and is downregulated in gastric cancer (GC).
In contrast, E2F1, an important transcription factor and tumor promoter, directly inhibits miR …
In contrast, E2F1, an important transcription factor and tumor promoter, directly inhibits miR …
Dynamical analysis of a boolean network model of the oncogene role of lncRNA ANRIL and lncRNA UFC1 in non-small cell lung cancer
Long non-coding RNA (lncRNA) such as ANRIL and UFC1 have been verified as oncogenic
genes in non-small cell lung cancer (NSCLC). It is well known that the tumor suppressor …
genes in non-small cell lung cancer (NSCLC). It is well known that the tumor suppressor …