Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

Abstract 'If G-quadruplexes form so readily in vitro, Nature will have found a way of using
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …

Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures
called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine …

Satellite DNA consists of abundant tandem repeats that play important roles in cellular
processes, including chromosome segregation, genome organization and chromosome end …

RNA structures in the untranslated regions (UTRs) of mRNAs influence post-transcriptional
regulation of gene expression. Much of the knowledge in this area depends on canonical …

Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …

Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

The G-quadruplex is an alternative DNA structural motif that is considered to be functionally
important in the mammalian genome for transcriptional regulation, DNA replication and …

While the discovery of B-form DNA 60 years ago has defined our molecular view of the
genetic code, other postulated DNA secondary structures, such as A-DNA, Z-DNA, H-DNA …

Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism …