Current trends in polymer microneedle for transdermal drug delivery

KAS Al-Japairai, S Mahmood, SH Almurisi… - International journal of …, 2020 - Elsevier
Transdermal drug delivery using microneedles is increasingly gaining interest due to the
issues associated with oral drug delivery routes. Gastrointestinal route exposes the drug to …

Microneedles for painless transdermal immunotherapeutic applications

H Amani, MA Shahbazi, C D'Amico, F Fontana… - Journal of Controlled …, 2021 - Elsevier
Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

[HTML][HTML] Recent advances of microneedles for biomedical applications: drug delivery and beyond

J Yang, X Liu, Y Fu, Y Song - Acta Pharmaceutica Sinica B, 2019 - Elsevier
The microneedle (MN), a highly efficient and versatile device, has attracted extensive
scientific and industrial interests in the past decades due to prominent properties including …

3D printed microneedles for anticancer therapy of skin tumours

MJ Uddin, N Scoutaris, SN Economidou… - Materials Science and …, 2020 - Elsevier
In this study, novel 3D printed polymeric microneedle arrays were fabricated for enhanced
cisplatin delivery to A-431 epidermoid skin tumours for cancer treatment. The microneedles …

Microneedles: a new generation vaccine delivery system

I Menon, P Bagwe, KB Gomes, L Bajaj, R Gala… - Micromachines, 2021 - mdpi.com
Transdermal vaccination route using biodegradable microneedles is a rapidly progressing
field of research and applications. The fear of painful needles is one of the primary reasons …

Chemical strategies to boost cancer vaccines

WH Li, YM Li - Chemical reviews, 2020 - ACS Publications
Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer

V Singh, P Kesharwani - Journal of Controlled Release, 2021 - Elsevier
Microneedles are unique, novel and an effective approach designed to deliver therapeutic
agents and immunobiologicals in several diseases. These tiny needle patches are designed …

Dissolvable polymer microneedles for drug delivery and diagnostics

M Ali, S Namjoshi, HAE Benson, Y Mohammed… - Journal of Controlled …, 2022 - Elsevier
Dissolvable transdermal microneedles (μND) are promising micro-devices used to transport
a wide selection of active compounds into the skin. To provide an effective therapeutic …

[HTML][HTML] Trends in drug-and vaccine-based dissolvable microneedle materials and methods of fabrication

LE Moore, S Vucen, AC Moore - European Journal of Pharmaceutics and …, 2022 - Elsevier
Microneedle patches, also called microarray patches (MAP), are an emerging technology for
delivery and sampling of drugs, vaccines and other materials. This review focuses on the …

Methods to improve the immunogenicity of plasmid DNA vaccines

D Eusébio, AR Neves, D Costa, S Biswas, G Alves… - Drug Discovery …, 2021 - Elsevier
DNA vaccines have emerged as innovative approaches that have great potential to
overcome the limitations of current conventional vaccines. Plasmid DNA vaccines are often …