WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Colorectal cancer (CRC), with its significant incidence and metastatic rates, profoundly
affects human health. A common oncogenic event in CRC is the aberrant activation of the …

Deregulated WNT signaling has been shown to favor malignant transformation, tumor
progression, and resistance to conventional cancer therapy in a variety of preclinical and …

The epithelial-mesenchymal transition (EMT) comprises an essential biological process
involving cancer progression as well as initiation. While the EMT has been regarded as a …

The term 'magic bullet'is a scientific concept proposed by the German Nobel laureate Paul
Ehrlich in 1907, describing a medicine that could specifically and efficiently target a disease …

Background/Aims Patients with advanced hepatocellular carcinoma (HCC) have a poor
prognosis due to the lack of effective systemic therapies. Epithelial-to-mesenchymal …

Niclosamide is a drug used to treat parasitic infections. Recent studies have shown that
niclosamide may have a wide range of clinical applications and can be used to treat cancer …

Digestive system cancers, mainly including gastric cancer, hepatocellular carcinoma,
pancreatic cancer, and colorectal cancer, are major public health problems and lead to …

The WNT/β-catenin signaling pathway plays crucial roles in tumorigenesis and relapse,
metastasis, drug resistance, and tumor stemness maintenance. In most tumors, the WNT/β …

Phosphorylation-dependent YAP translocation is a well-known intracellular mechanism of
the Hippo pathway; however, the molecular effectors governing YAP cytoplasmic …