Photo‐Lipids: Light‐Sensitive Nano‐Switches to Control Membrane Properties

L Socrier, C Steinem - ChemPlusChem, 2023 - Wiley Online Library
Biological membranes are described as a complex mixture of lipids and proteins organized
according to thermodynamic principles. This chemical and spatial complexity can lead to …

Light‐Activated Synthetic Rotary Motors in Lipid Membranes Induce Shape Changes Through Membrane Expansion

Y Qutbuddin, A Guinart, S Gavrilović… - Advanced …, 2024 - Wiley Online Library
Membranes are the key structures to separate and spatially organize cellular systems. Their
rich dynamics and transformations during the cell cycle are orchestrated by specific …

Photomanipulation of Minimal Synthetic Cells: Area Increase, Softening, and Interleaflet Coupling of Membrane Models Doped with Azobenzene‐Lipid Photoswitches

M Aleksanyan, A Grafmüller, F Crea… - Advanced …, 2023 - Wiley Online Library
Light can effectively interrogate biological systems in a reversible and physiologically
compatible manner with high spatiotemporal precision. Understanding the biophysics of …

Photolipid excitation triggers depolarizing optocapacitive currents and action potentials

CAZ Bassetto Jr, J Pfeffermann, R Yadav… - Nature …, 2024 - nature.com
Optically-induced changes in membrane capacitance may regulate neuronal activity without
requiring genetic modifications. Previously, they mainly relied on sudden temperature jumps …

[HTML][HTML] Alteration of Average Thickness of Lipid Bilayer by Membrane-Deforming Inclusions

OV Kondrashov, SA Akimov - Biomolecules, 2023 - mdpi.com
Thickness of lipid bilayer membranes is a key physical parameter determining membrane
permeability and stability with respect to formation of through pores. Most membrane …

Photoinduced bidirectional switching in lipid membranes containing azobenzene glycolipids

JE Warias, F Reise, SC Hövelmann, RP Giri, M Röhrl… - Scientific reports, 2023 - nature.com
Following the reaction of biological membranes to external stimuli reveals fundamental
insights into cellular function. Here, self-assembled lipid monolayers act as model …

Photoswitchable TRPC6 channel activators evoke distinct channel kinetics reflecting different gating behaviors

M Keck, C Hermann, K Lützel, T Gudermann… - Iscience, 2024 - cell.com
The non-selective transient receptor potential canonical 6 (TRPC6) cation channels have
several physiological and pathophysiological effects. They are activated by the lipid second …

SAXS measurements of azobenzene lipid vesicles reveal buffer-dependent photoswitching and quantitative Z→E isomerisation by X-rays

MF Ober, A Müller-Deku, A Baptist, B Ajanović… - …, 2022 - degruyter.com
Photoresponsive materials feature properties that can be adjusted by light near-
instantaneously, reversibly, and with high spatiotemporal precision. There is considerable …

Gramicidin A as a mechanical sensor for mixed nonideal lipid membranes

OV Kondrashov, SA Akimov - Physical Review E, 2024 - APS
Gramicidin A (gA) is a short hydrophobic β-helical peptide that forms cation-selective
channels in lipid membranes in the course of transbilayer dimerization. The length of the gA …

[HTML][HTML] Photodynamic activity rather than drilling causes membrane damage by a light-powered molecular nanomotor

AM Firsov, J Pfeffermann, AS Benditkis… - … of Photochemistry and …, 2023 - Elsevier
The chase toward endowing chemical compounds with machine-like functions mimicking
those of biological molecular machineries has yielded a variety of artificial molecular motors …