Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy
XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …
Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration
DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …
Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization
J Zhao, X Li, J Hu, F Chen, S Qiao, X Sun… - Cardiovascular …, 2019 - academic.oup.com
Abstract Aims Mesenchymal stromal cells (MSCs) gradually become attractive candidates
for cardiac inflammation modulation, yet understanding of the mechanism remains elusive …
for cardiac inflammation modulation, yet understanding of the mechanism remains elusive …
Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …
Concise review: MSC-derived exosomes for cell-free therapy
DG Phinney, MF Pittenger - Stem cells, 2017 - academic.oup.com
Mesenchymal stem cell transplantation is undergoing extensive evaluation as a cellular
therapy in human clinical trials. Because MSCs are easily isolated and amenable to culture …
therapy in human clinical trials. Because MSCs are easily isolated and amenable to culture …
Insights into the secretome of mesenchymal stem cells and its potential applications
S Eleuteri, A Fierabracci - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …
MSC exosome works through a protein-based mechanism of action
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
MiRNA-mediated macrophage polarization and its potential role in the regulation of inflammatory response
Monocytes and macrophages are important components of the immune system, specialized
in either removing pathogens as part of innate immunity or contributing to adaptive immunity …
in either removing pathogens as part of innate immunity or contributing to adaptive immunity …
Exosomal miR-146a contributes to the enhanced therapeutic efficacy of interleukin-1β-primed mesenchymal stem cells against sepsis
Y Song, H Dou, X Li, X Zhao, Y Li, D Liu, J Ji, F Liu… - Stem …, 2017 - academic.oup.com
Improving the immunomodulatory efficacy of mesenchymal stem cells (MSCs) through
pretreatment with pro-inflammatory cytokines is an evolving field of investigation. However …
pretreatment with pro-inflammatory cytokines is an evolving field of investigation. However …
Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
After the initial investigations into applications of mesenchymal stem cells (MSCs) for cell
therapy, there was increased interest in their secreted soluble factors. Following studies of …
therapy, there was increased interest in their secreted soluble factors. Following studies of …