Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

J Zhao, X Li, J Hu, F Chen, S Qiao, X Sun… - Cardiovascular …, 2019 - academic.oup.com
Abstract Aims Mesenchymal stromal cells (MSCs) gradually become attractive candidates
for cardiac inflammation modulation, yet understanding of the mechanism remains elusive …

Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases

S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …

Concise review: MSC-derived exosomes for cell-free therapy

DG Phinney, MF Pittenger - Stem cells, 2017 - academic.oup.com
Mesenchymal stem cell transplantation is undergoing extensive evaluation as a cellular
therapy in human clinical trials. Because MSCs are easily isolated and amenable to culture …

Insights into the secretome of mesenchymal stem cells and its potential applications

S Eleuteri, A Fierabracci - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …

MSC exosome works through a protein-based mechanism of action

WS Toh, RC Lai, B Zhang, SK Lim - Biochemical Society …, 2018 - portlandpress.com
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …

MiRNA-mediated macrophage polarization and its potential role in the regulation of inflammatory response

K Essandoh, Y Li, J Huo, GC Fan - Shock, 2016 - journals.lww.com
Monocytes and macrophages are important components of the immune system, specialized
in either removing pathogens as part of innate immunity or contributing to adaptive immunity …

Exosomal miR-146a contributes to the enhanced therapeutic efficacy of interleukin-1β-primed mesenchymal stem cells against sepsis

Y Song, H Dou, X Li, X Zhao, Y Li, D Liu, J Ji, F Liu… - Stem …, 2017 - academic.oup.com
Improving the immunomodulatory efficacy of mesenchymal stem cells (MSCs) through
pretreatment with pro-inflammatory cytokines is an evolving field of investigation. However …

Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

KS Park, E Bandeira, GV Shelke, C Lässer… - Stem cell research & …, 2019 - Springer
After the initial investigations into applications of mesenchymal stem cells (MSCs) for cell
therapy, there was increased interest in their secreted soluble factors. Following studies of …