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The variable in common variable immunodeficiency: a disease of complex phenotypes
S Jolles - The Journal of Allergy and Clinical Immunology: In …, 2013 - Elsevier
Common variable immunodeficiency (CVID) is the most common and clinically most
important severe primary antibody deficiency and is characterized by low levels of IgG, IgA …
important severe primary antibody deficiency and is characterized by low levels of IgG, IgA …
Beyond the extra respiration of phagocytosis: NADPH oxidase 2 in adaptive immunity and inflammation
PM Mortimer, SA Mc Intyre, DC Thomas - Frontiers in Immunology, 2021 - frontiersin.org
Reactive oxygen species (ROS) derived from the phagocyte NADPH oxidase (NOX2) are
essential for host defence and immunoregulation. Their levels must be tightly controlled …
essential for host defence and immunoregulation. Their levels must be tightly controlled …
The EUROclass trial: defining subgroups in common variable immunodeficiency
C Wehr, T Kivioja, C Schmitt, B Ferry… - Blood, The Journal …, 2008 - ashpublications.org
The heterogeneity of common variable immunodeficiency (CVID) calls for a classification
addressing pathogenic mechanisms as well as clinical relevance. This European …
addressing pathogenic mechanisms as well as clinical relevance. This European …
Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature
T Kelkka, D Kienhöfer, M Hoffmann, M Linja… - Antioxidants & redox …, 2014 - liebertpub.com
Aims: Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by
mutations in the phagocyte reactive oxygen species (ROS)–producing NOX2 enzyme …
mutations in the phagocyte reactive oxygen species (ROS)–producing NOX2 enzyme …
The plasma membrane: a platform for intra-and intercellular redox signaling
DE Nordzieke, I Medraño-Fernandez - Antioxidants, 2018 - mdpi.com
Membranes are of outmost importance to allow for specific signal transduction due to their
ability to localize, amplify, and direct signals. However, due to the double-edged nature of …
ability to localize, amplify, and direct signals. However, due to the double-edged nature of …
[HTML][HTML] Recent advances in chronic granulomatous disease
G Anjani, P Vignesh, V Joshi, JK Shandilya… - Genes & diseases, 2020 - Elsevier
Chronic granulomatous disease (CGD) is an inherited defect of phagocyte function due to
defective NADPH oxidase. Patients with CGD are not able to effectively clear the infections …
defective NADPH oxidase. Patients with CGD are not able to effectively clear the infections …
Inflammatory manifestations in chronic granulomatous disease (CGD)
SD Rosenzweig - Journal of Clinical Immunology, 2008 - Springer
Chronic granulomatous disease (CGD) is a genetically heterogeneous disease
characterized by recurrent life-threatening infections with bacteria and fungi as well as …
characterized by recurrent life-threatening infections with bacteria and fungi as well as …
Differentiation of common variable immunodeficiency from IgG deficiency
CA Filion, S Taylor-Black, PJ Maglione… - The Journal of Allergy …, 2019 - Elsevier
Background Common variable immunodeficiency (CVID) and IgG deficiency are 2 of the
more prevalent primary humoral immune defects. The former is defined by consensus with …
more prevalent primary humoral immune defects. The former is defined by consensus with …
T and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency
MLG Ochtrop, S Goldacker, AM May… - Blood, The Journal …, 2011 - ashpublications.org
In common variable immunodeficiency (CVID) defects in early stages of B-cell development,
bone marrow (BM) plasma cells and T lymphocytes have not been studied systematically …
bone marrow (BM) plasma cells and T lymphocytes have not been studied systematically …
Reactive oxygen species: the signal regulator of B cell
Reactive oxygen species (ROS) are indispensable for determining the fate of immune cells
in both physiological and pathogenic environments, thus stimulating the interest of …
in both physiological and pathogenic environments, thus stimulating the interest of …