Novel 1, 3-thiazole analogues with potent activity against breast cancer: A design, synthesis, in vitro, and in silico study
MG Salem, DMA El-Maaty, YIM El-Deen, BH Elesawy… - Molecules, 2022 - mdpi.com
Breast cancer is the most common cancer in women, responsible for over half a million
deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen-and sulfur …
deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen-and sulfur …
Develo** our knowledge of the quinolone scaffold and its value to anticancer drug design
Introduction The quinolone scaffold is a bicyclic benzene-pyridinic ring scaffold with nitrogen
at the first position and a carbonyl group at the second or fourth position. It is endowed with a …
at the first position and a carbonyl group at the second or fourth position. It is endowed with a …
[HTML][HTML] A Review of Cinnamic Acid's Skeleton Modification: Features for Antibacterial-Agent-Guided Derivatives
Antimicrobial resistance has emerged as a significant danger to global health, and the need
for more effective antimicrobial resistance (AMR) control has been highlighted. Cinnamic …
for more effective antimicrobial resistance (AMR) control has been highlighted. Cinnamic …
Design, synthesis, and characterization of cinnamic acid derivatives with two novel acrylohydrazones on HeLa and CHO-1 cancer cell lines: the experimental and …
Purpose To investigate the effect of derivatives of cinnamic acid on the proliferation of CHO-
1 and HeLa cell lines. Methods Three Acrylohydrazones (7–9) derived from cinnamic acid …
1 and HeLa cell lines. Methods Three Acrylohydrazones (7–9) derived from cinnamic acid …
Synthesis and anticancer evaluation of novel 7-aza-coumarine-3-carboxamides
AV Trifonov, AS Gazizov, AS Tapalova… - International Journal of …, 2023 - mdpi.com
Herein, we report the design and synthesis of novel 7-aza-coumarine-3-carboxamides via
scaffold-hop** strategy and evaluation of their in vitro anticancer activity. Additionally, the …
scaffold-hop** strategy and evaluation of their in vitro anticancer activity. Additionally, the …
Design, synthesis and evaluation the bioactivities of novel 8‑methoxy-1-azacoumarin-3-carboxamide derivatives as anti-diabetic agents
In this study, a novel series of 8‑methoxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid and
N-substituted 8‑methoxy-2-oxo-1, 2-dihydroquinoline-3-carboxamide derivatives 2–10 were …
N-substituted 8‑methoxy-2-oxo-1, 2-dihydroquinoline-3-carboxamide derivatives 2–10 were …
In vitro anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety
Aim: To synthesize new hybrid cinnamic acids (10a, 10b and 11) and ester derivatives (7, 8
and 9) and investigate their anti-breast cancer activities. Materials & methods: Compounds 7 …
and 9) and investigate their anti-breast cancer activities. Materials & methods: Compounds 7 …
Anticancer Studies of Newly Synthesized Thiazole Derivatives: Synthesis, Characterization, Biological Activity, and Molecular Docking
Thiazole and its derivatives have received a lot of attention from researchers due to its wide
biological, pharmacological, and anticancer properties. A novel series of 2-[2-[4-Hydroxy-3 …
biological, pharmacological, and anticancer properties. A novel series of 2-[2-[4-Hydroxy-3 …
Study of Biological Activities and ADMET-Related Properties of Novel Chlorinated N-arylcinnamamides
T Strharsky, D Pindjakova, J Kos, L Vrablova… - International Journal of …, 2022 - mdpi.com
A series of eighteen 4-chlorocinnamanilides and eighteen 3, 4-dichlorocinnamanilides were
designed, prepared and characterized. All compounds were evaluated for their activity …
designed, prepared and characterized. All compounds were evaluated for their activity …
Cinnamamide derivatives with 4-hydroxypiperidine moiety enhance effect of doxorubicin to cancer cells and protect cardiomyocytes against drug-induced toxicity …
P Koczurkiewicz-Adamczyk, B Gąsiorkiewicz, K Piska… - Life Sciences, 2022 - Elsevier
Doxorubicin (DOX) is classified by World Health Organization (WHO) as an essential
medicine for cancer. However, its clinical application is limited due to resistance …
medicine for cancer. However, its clinical application is limited due to resistance …