Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Occupational injuries and toxicant exposures lead to the development of neuroinflammation
by activating distinct mechanistic signaling cascades that ultimately culminate in the …

Considerable debate exists in the literature on how best to measure infarct damage and at
what point after middle cerebral artery occlusion (MCAO) infarct is histologically complete …

Background Investigations following stroke first of all require information about the spatio-
temporal dimension of the ischemic core as well as of perilesional and remote affected …

Progress in treating ischemic stroke (IS) and its delayed consequences has been
frustratingly slow due to the insufficient knowledge on the mechanism. One important factor …

Proinflammatory cytokines and chemokines have been implicated in the pathogenesis of
several neurological and neurodegenerative disorders. Prominent among such factors is the …

Cerebral ischemia is a result of insufficient blood flow to the brain. It leads to limited supply
of oxygen and other nutrients to meet metabolic demands. These phenomena lead to brain …

Focal brain lesions can lead to metabolic and structural changes in areas distant from but
connected to the lesion site. After focal ischemic or excitotoxic lesions of the cortex and/or …

Ischemic strokes are categorized by permanent or transient obstruction of blood flow, which
impedes delivery of oxygen and essential nutrients to brain. In the last decade, the …

Two classical surgical approaches for intraluminal filament middle cerebral artery occlusion
(MCAO), the Longa et al.(LM) and Koizumi et al. methods (KM), are used as alternatives in …