Apoptosis, programmed cell death type I, is a critical part of neurodegeneration in cerebral
ischemia, Parkinson's, and Alzheimer's disease. Apoptosis begins with activation of pro …

B-cell lymphoma-extra large (Bcl-X L) is one of the anti-apoptotic proteins of the Bcl-2 family
that is localized in the mitochondria. Bcl-X L is one of the key regulators of apoptosis that can …

Familial Parkinson's disease (PD) protein DJ-1 mutations are linked to early onset PD. We
have found that DJ-1 binds directly to the F1FO ATP synthase β subunit. DJ-1's interaction …

Ion transport across the mitochondrial inner and outer membranes is central to mitochondrial
function, including regulation of oxidative phosphorylation and cell death. Although essential …

Parkinson's disease (PD) is the most common movement disorder and the second most
prevalent neurodegenerative disease after Alzheimer's disease. Despite decades of …

In recent years, rehabilitation of ischemic stroke draws more and more attention in the world,
and has been linked to changes of synaptic plasticity. Exercise training improves motor …

Erythropoietin is a cytokine that binds to the Erythropoietin receptor and regulates the
formation of erythroid cells during erythropoiesis in the bone marrow. However, many other …

Apoptosis plays an essential role during brain development, yet the precise mechanism by
which this pathway is regulated in the brain remains unknown. In particular, mammalian …

Brain ischemic preconditioning (PC) provides vital insights into the endogenous protection
against stroke. Genomic and epigenetic responses to PC condition the brain into a state of …

Anthocyanin-rich foods, such as berries, reportedly ameliorate age-related cognitive deficits
in both animals and humans. Despite this, investigation into the mechanisms which …