Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Numerous proteins, including cytokines and chemokines, enzymes and enzyme inhibitors,
extracellular matrix proteins, and membrane receptors, bind heparin. Although they are …

Recent studies suggest that mitochondria can be transferred between cells to support the
survival of metabolically compromised cells. However, whether intercellular mitochondria …

Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

We show that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and
dyslipidemia in obese rodents by sensitizing insulin signaling. Activation or overexpression …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These
complex polysaccharides provide docking sites for numerous protein ligands and receptors …

1372 Heparin and anticoagulation Akihiro Onishi1, Kalib St Ange1, Jonathan S. Dordick1, Robert
J. Linhardt1 1Center for Biotechn Page 1 1372 [Frontiers in Bioscience, Landmark, 21 …

Two major glycosaminoglycan types, heparan sulfate (HS) and chondroitin sulfate (CS),
control many aspects of development and physiology in a type-specific manner. HS and CS …

Proteoglycans (PGs) represent a large proportion of the components that constitute the
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …